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Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

The product of the p53 gene suppresses cell growth and plays a critical role in suppressing development of human tumors. p53 protein binds DNA, activates transcription, and can be phosphorylated at N- and C-terminal sites. Previously, wild-type p53 was shown to be hyperphosphorylated compared to mut...

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Bibliografische gegevens
Hoofdauteurs: Ullrich, S J, Sakaguchi, K, Lees-Miller, S P, Fiscella, M, Mercer, W E, Anderson, C W, Appella, E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC46845/
https://ncbi.nlm.nih.gov/pubmed/8327466
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