Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

The product of the p53 gene suppresses cell growth and plays a critical role in suppressing development of human tumors. p53 protein binds DNA, activates transcription, and can be phosphorylated at N- and C-terminal sites. Previously, wild-type p53 was shown to be hyperphosphorylated compared to mut...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ullrich, S J, Sakaguchi, K, Lees-Miller, S P, Fiscella, M, Mercer, W E, Anderson, C W, Appella, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46845/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8327466/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.13.5954
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