Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

Stabilization of p53 in response to DNA damage is caused by its dissociation from Mdm2, a protein that targets p53 for degradation in the proteasome. Dissociation of p53 from Mdm2 could be caused by DNA damage-induced p53 posttranslational modifications. The ATM and ATR kinases, whose activation in...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chehab, Nabil H., Malikzay, Asra, Stavridi, Elena S., Halazonetis, Thanos D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24141/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570149/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13777
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!