p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

DNA binding activity of p53 is crucial for its tumor suppressor function. Our recent studies have shown that four molecules of the DNA binding domain of human p53 (p53DBD) bind the response elements with high cooperativity and bend the DNA. By using A-tract phasing experiments, we find significant d...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Nagaich, Akhilesh K., Zhurkin, Victor B., Durell, Stewart R., Jernigan, Robert L., Appella, Ettore, Harrington, Rodney E.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1999
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26704/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051562/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1875
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