p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

DNA binding activity of p53 is crucial for its tumor suppressor function. Our recent studies have shown that four molecules of the DNA binding domain of human p53 (p53DBD) bind the response elements with high cooperativity and bend the DNA. By using A-tract phasing experiments, we find significant d...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Nagaich, Akhilesh K., Zhurkin, Victor B., Durell, Stewart R., Jernigan, Robert L., Appella, Ettore, Harrington, Rodney E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26704/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051562/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1875
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