p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

DNA binding activity of p53 is crucial for its tumor suppressor function. Our recent studies have shown that four molecules of the DNA binding domain of human p53 (p53DBD) bind the response elements with high cooperativity and bend the DNA. By using A-tract phasing experiments, we find significant d...

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Detaylı Bibliyografya
Asıl Yazarlar: Nagaich, Akhilesh K., Zhurkin, Victor B., Durell, Stewart R., Jernigan, Robert L., Appella, Ettore, Harrington, Rodney E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 1999
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC26704/
https://ncbi.nlm.nih.gov/pubmed/10051562
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