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Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

Recent structural studies of the minimal core DNA-binding domain of p53 (p53DBD) complexed to a single consensus pentamer sequence and of the isolated p53 tetramerization domain have provided valuable insights into their functions, but many questions about their interacting roles and synergism remai...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Balagurumoorthy, P, Sakamoto, H, Lewis, M S, Zambrano, N, Clore, G M, Gronenborn, A M, Appella, E, Harrington, R E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41012/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7567980/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.19.8591
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