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Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase β
DNA polymerase β (Polβ) has been implicated in base excision repair in mammalian cells. However, the physiological significance of this enzyme in the body remains unclear. Here, we demonstrate that mice carrying a targeted disruption of the Polβ gene showed growth retardation and died of a respirato...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305680/ https://ncbi.nlm.nih.gov/pubmed/10716939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.6.1397 |
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