Novel p21-activated kinase 4 (PAK4) allosteric modulators overcome drug resistance and stemness in pancreatic ductal adenocarcinoma

The p21-activated kinase 4 (PAK4) is a key downstream effector of the Rho family GTPases and is found to be over-expressed in pancreatic ductal adenocarcinoma (PDAC) cells but not in normal human pancreatic ductal epithelia (HPDE). Gene copy number amplification studies in PDAC patient cohorts confi...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Aboukameel, Amro, Muqbil, Irfana, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Philip, Philip A., Mohammad, Ramzi M., Azmi, Asfar S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221563/
https://ncbi.nlm.nih.gov/pubmed/28062705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0205
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