Ketolide Antimicrobial Activity Persists after Disruption of Interactions with Domain II of 23S rRNA

Ketolides are the latest derivatives developed from the macrolide erythromycin to improve antimicrobial activity. All macrolides and ketolides bind to the 50S ribosomal subunit, where they come into contact with adenosine 2058 (A2058) within domain V of the 23S rRNA and block protein synthesis. An a...

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Bibliographic Details
Main Authors: Novotny, Guy W., Jakobsen, Lene, Andersen, Niels M., Poehlsgaard, Jacob, Douthwaite, Stephen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC521900/
https://ncbi.nlm.nih.gov/pubmed/15388419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.10.3677-3683.2004
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