Ketolide Antimicrobial Activity Persists after Disruption of Interactions with Domain II of 23S rRNA

Ketolides are the latest derivatives developed from the macrolide erythromycin to improve antimicrobial activity. All macrolides and ketolides bind to the 50S ribosomal subunit, where they come into contact with adenosine 2058 (A2058) within domain V of the 23S rRNA and block protein synthesis. An a...

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Bibliografiska uppgifter
Huvudupphovsmän: Novotny, Guy W., Jakobsen, Lene, Andersen, Niels M., Poehlsgaard, Jacob, Douthwaite, Stephen
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
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Mechanisms of Action: Physiological Effects
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC521900/
https://ncbi.nlm.nih.gov/pubmed/15388419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.10.3677-3683.2004
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