Ketolide Antimicrobial Activity Persists after Disruption of Interactions with Domain II of 23S rRNA

Ketolides are the latest derivatives developed from the macrolide erythromycin to improve antimicrobial activity. All macrolides and ketolides bind to the 50S ribosomal subunit, where they come into contact with adenosine 2058 (A2058) within domain V of the 23S rRNA and block protein synthesis. An a...

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Detalhes bibliográficos
Main Authors: Novotny, Guy W., Jakobsen, Lene, Andersen, Niels M., Poehlsgaard, Jacob, Douthwaite, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC521900/
https://ncbi.nlm.nih.gov/pubmed/15388419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.10.3677-3683.2004
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