Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin (mTOR). Because mTOR signaling is required for initiation of messenger RNA translation, we hypothesized that cotargeting the PI3K and proteasome pathways might synergistica...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Deng, Changchun, Lipstein, Mark R., Scotto, Luigi, Jirau Serrano, Xavier O., Mangone, Michael A., Li, Shirong, Vendome, Jeremie, Hao, Yun, Xu, Xiaoming, Deng, Shi-Xian, Realubit, Ronald B., Tatonetti, Nicholas P., Karan, Charles, Lentzsch, Suzanne, Fruman, David A., Honig, Barry, Landry, Donald W., O’Connor, Owen A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216267/
https://ncbi.nlm.nih.gov/pubmed/27784673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-731240
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