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Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin (mTOR). Because mTOR signaling is required for initiation of messenger RNA translation, we hypothesized that cotargeting the PI3K and proteasome pathways might synergistica...

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Τόπος έκδοσης:	Blood
Κύριοι συγγραφείς:	Deng, Changchun, Lipstein, Mark R., Scotto, Luigi, Jirau Serrano, Xavier O., Mangone, Michael A., Li, Shirong, Vendome, Jeremie, Hao, Yun, Xu, Xiaoming, Deng, Shi-Xian, Realubit, Ronald B., Tatonetti, Nicholas P., Karan, Charles, Lentzsch, Suzanne, Fruman, David A., Honig, Barry, Landry, Donald W., O’Connor, Owen A.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society of Hematology 2017
Θέματα:	Lymphoid Neoplasia
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5216267/ https://ncbi.nlm.nih.gov/pubmed/27784673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-731240
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Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

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