Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin (mTOR). Because mTOR signaling is required for initiation of messenger RNA translation, we hypothesized that cotargeting the PI3K and proteasome pathways might synergistica...

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Detalhes bibliográficos
Publicado no:Blood
Principais autores: Deng, Changchun, Lipstein, Mark R., Scotto, Luigi, Jirau Serrano, Xavier O., Mangone, Michael A., Li, Shirong, Vendome, Jeremie, Hao, Yun, Xu, Xiaoming, Deng, Shi-Xian, Realubit, Ronald B., Tatonetti, Nicholas P., Karan, Charles, Lentzsch, Suzanne, Fruman, David A., Honig, Barry, Landry, Donald W., O’Connor, Owen A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216267/
https://ncbi.nlm.nih.gov/pubmed/27784673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-731240
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