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Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies
Phosphoinositide 3-kinase (PI3K) and the proteasome pathway are both involved in activating the mechanistic target of rapamycin (mTOR). Because mTOR signaling is required for initiation of messenger RNA translation, we hypothesized that cotargeting the PI3K and proteasome pathways might synergistica...
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Publié dans: | Blood |
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Auteurs principaux: | , , , , , , , , , , , , , , , , , |
Format: | Artigo |
Langue: | Inglês |
Publié: |
American Society of Hematology
2017
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5216267/ https://ncbi.nlm.nih.gov/pubmed/27784673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-731240 |
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