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A balance between elongation and trimming regulates telomere stability in stem cells

Telomere length maintenance ensures self-renewal of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), however the mechanisms governing telomere length homeostasis in these cell types are unclear. Here, we report that telomere length is determined by the balance between t...

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Détails bibliographiques
Publié dans:Nat Struct Mol Biol
Auteurs principaux: Rivera, Teresa, Haggblom, Candy, Cosconati, Sandro, Karlseder, Jan
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215970/
https://ncbi.nlm.nih.gov/pubmed/27918544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3335
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