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A balance between elongation and trimming regulates telomere stability in stem cells

Telomere length maintenance ensures self-renewal of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), however the mechanisms governing telomere length homeostasis in these cell types are unclear. Here, we report that telomere length is determined by the balance between t...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Rivera, Teresa, Haggblom, Candy, Cosconati, Sandro, Karlseder, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215970/
https://ncbi.nlm.nih.gov/pubmed/27918544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3335
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