MAR‐Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non‐homologous end‐joining (NHEJ) or homologous recombination (HR) DNA repair pathways. Howev...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Biotechnol Bioeng
Autors principals: Kostyrko, Kaja, Neuenschwander, Samuel, Junier, Thomas, Regamey, Alexandre, Iseli, Christian, Schmid‐Siegert, Emanuel, Bosshard, Sandra, Majocchi, Stefano, Le Fourn, Valérie, Girod, Pierre‐Alain, Xenarios, Ioannis, Mermod, Nicolas
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215416/
https://ncbi.nlm.nih.gov/pubmed/27575535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26086
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars