Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release

The Chinese hamster ovary (CHO) cells used to produce biopharmaceutical proteins are known to contain type‐C endogenous retrovirus (ERV) sequences in their genome and to release retroviral‐like particles. Although evidence for their infectivity is missing, this has raised safety concerns. As the gen...

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Detalhes bibliográficos
Publicado no:Biotechnol Bioeng
Main Authors: Duroy, Pierre‐Olivier, Bosshard, Sandra, Schmid‐Siegert, Emanuel, Neuenschwander, Samuel, Arib, Ghislaine, Lemercier, Philippe, Masternak, Jacqueline, Roesch, Lucien, Buron, Flavien, Girod, Pierre‐Alain, Xenarios, Ioannis, Mermod, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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ARTICLES
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003738/
https://ncbi.nlm.nih.gov/pubmed/31631325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27200
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