Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release

The Chinese hamster ovary (CHO) cells used to produce biopharmaceutical proteins are known to contain type‐C endogenous retrovirus (ERV) sequences in their genome and to release retroviral‐like particles. Although evidence for their infectivity is missing, this has raised safety concerns. As the gen...

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Vydáno v:Biotechnol Bioeng
Hlavní autoři: Duroy, Pierre‐Olivier, Bosshard, Sandra, Schmid‐Siegert, Emanuel, Neuenschwander, Samuel, Arib, Ghislaine, Lemercier, Philippe, Masternak, Jacqueline, Roesch, Lucien, Buron, Flavien, Girod, Pierre‐Alain, Xenarios, Ioannis, Mermod, Nicolas
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003738/
https://ncbi.nlm.nih.gov/pubmed/31631325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27200
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