MAR‐Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non‐homologous end‐joining (NHEJ) or homologous recombination (HR) DNA repair pathways. Howev...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biotechnol Bioeng
Main Authors: Kostyrko, Kaja, Neuenschwander, Samuel, Junier, Thomas, Regamey, Alexandre, Iseli, Christian, Schmid‐Siegert, Emanuel, Bosshard, Sandra, Majocchi, Stefano, Le Fourn, Valérie, Girod, Pierre‐Alain, Xenarios, Ioannis, Mermod, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215416/
https://ncbi.nlm.nih.gov/pubmed/27575535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26086
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados