Influence of cytoskeleton organization on recombinant protein expression by CHO cells

In this study, we assessed the importance of cytoskeleton organization in the mammalian cells used to produce therapeutic proteins. Two cytoskeletal genes, Actin alpha cardiac muscle 1 (ACTC1) and a guanosine triphosphate GTPase‐activating protein (TAGAP), were found to be upregulated in highly prod...

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Vydáno v:Biotechnol Bioeng
Hlavní autoři: Pourcel, Lucille, Buron, Flavien, Arib, Ghislaine, Le Fourn, Valérie, Regamey, Alexandre, Bodenmann, Iris, Girod, Pierre‐Alain, Mermod, Nicolas
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079171/
https://ncbi.nlm.nih.gov/pubmed/31956990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27277
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