A network of conserved synthetic lethal interactions for exploration of precision cancer therapy

An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here, we use a multi-species approach to develop a resource of synthetic-lethal interactions among genes mutated in cancer, incl...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Srivas, Rohith, Shen, John Paul, Yang, Chih Cheng, Sun, Su Ming, Li, Jianfeng, Gross, Andrew M., Jensen, James, Licon, Katherine, Bojorquez-Gomez, Ana, Klepper, Kristin, Huang, Justin, Pekin, Daniel, Xu, Jia L., Yeerna, Huwate, Sivaganesh, Vignesh, Kollenstart, Leonie, van Attikum, Haico, Aza-Blanc, Pedro, Sobol, Robert W., Ideker, Trey
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209245/
https://ncbi.nlm.nih.gov/pubmed/27453043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.06.022
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