Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition

Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we screened 112 known tumor suppressor genes for synt...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Shen, John Paul, Srivas, Rohith, Gross, Andrew, Li, Jianfeng, Jaehnig, Eric J., Sun, Su Ming, Bojorquez-Gomez, Ana, Licon, Katherine, Sivaganesh, Vignesh, Xu, Jia L., Klepper, Kristin, Yeerna, Huwate, Pekin, Daniel, Qiu, Chu Ping, van Attikum, Haico, Sobol, Robert W., Ideker, Trey
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742139/
https://ncbi.nlm.nih.gov/pubmed/26437225
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