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DNA methylation in the gene body influences MeCP2-mediated gene repression

Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is proposed to function as a transcriptional repressor. However, multiple gene expression studies comparing wild-type and MeCP2-de...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Kinde, Benyam, Wu, Dennis Y., Greenberg, Michael E., Gabel, Harrison W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206576/
https://ncbi.nlm.nih.gov/pubmed/27965390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618737114
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