Disruption of DNA methylation-dependent long gene repression in Rett syndrome

Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder with features of autism(1). MECP2 encodes a methyl-DNA-binding protein(2) that has been proposed to function as a transcriptional repressor, but despite numerous studies examining neuronal gene expression in Me...

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Pubblicato in:Nature
Autori principali: Gabel, Harrison W., Kinde, Benyam Z., Stroud, Hume, Gilbert, Caitlin S., Harmin, David A., Kastan, Nathaniel R., Hemberg, Martin, Ebert, Daniel H., Greenberg, Michael E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480648/
https://ncbi.nlm.nih.gov/pubmed/25762136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14319
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