Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5

Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in cancer and are often associated with progression from benign to invasive stages with metastatic potential. Mutations inactivate tumor suppression by p53, and some endow the protein with novel gain of function (GOF...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Vogiatzi, Fotini, Brandt, Dominique T., Schneikert, Jean, Fuchs, Jeannette, Grikscheit, Katharina, Wanzel, Michael, Pavlakis, Evangelos, Charles, Joël P., Timofeev, Oleg, Nist, Andrea, Mernberger, Marco, Kantelhardt, Eva J., Siebolts, Udo, Bartel, Frank, Jacob, Ralf, Rath, Ariane, Moll, Roland, Grosse, Robert, Stiewe, Thorsten
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206569/
https://ncbi.nlm.nih.gov/pubmed/27956623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612711114
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