Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses

Engineered p53 mutant mice are valuable tools for delineating p53 functions in tumor suppression and cancer therapy. Here, we have introduced the R178E mutation into the Trp53 gene of mice to specifically ablate the cooperative nature of p53 DNA binding. Trp53 (R178E) mice show no detectable target...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Timofeev, Oleg, Klimovich, Boris, Schneikert, Jean, Wanzel, Michael, Pavlakis, Evangelos, Noll, Julia, Mutlu, Samet, Elmshäuser, Sabrina, Nist, Andrea, Mernberger, Marco, Lamp, Boris, Wenig, Ulrich, Brobeil, Alexander, Gattenlöhner, Stefan, Köhler, Kernt, Stiewe, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792016/
https://ncbi.nlm.nih.gov/pubmed/31483066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102096
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