Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses

Engineered p53 mutant mice are valuable tools for delineating p53 functions in tumor suppression and cancer therapy. Here, we have introduced the R178E mutation into the Trp53 gene of mice to specifically ablate the cooperative nature of p53 DNA binding. Trp53 (R178E) mice show no detectable target...

全面介紹

Na minha lista:
書目詳細資料
發表在:EMBO J
Main Authors: Timofeev, Oleg, Klimovich, Boris, Schneikert, Jean, Wanzel, Michael, Pavlakis, Evangelos, Noll, Julia, Mutlu, Samet, Elmshäuser, Sabrina, Nist, Andrea, Mernberger, Marco, Lamp, Boris, Wenig, Ulrich, Brobeil, Alexander, Gattenlöhner, Stefan, Köhler, Kernt, Stiewe, Thorsten
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
主題:
Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792016/
https://ncbi.nlm.nih.gov/pubmed/31483066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102096
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍