Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5

Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in cancer and are often associated with progression from benign to invasive stages with metastatic potential. Mutations inactivate tumor suppression by p53, and some endow the protein with novel gain of function (GOF...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vogiatzi, Fotini, Brandt, Dominique T., Schneikert, Jean, Fuchs, Jeannette, Grikscheit, Katharina, Wanzel, Michael, Pavlakis, Evangelos, Charles, Joël P., Timofeev, Oleg, Nist, Andrea, Mernberger, Marco, Kantelhardt, Eva J., Siebolts, Udo, Bartel, Frank, Jacob, Ralf, Rath, Ariane, Moll, Roland, Grosse, Robert, Stiewe, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206569/
https://ncbi.nlm.nih.gov/pubmed/27956623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612711114
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