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Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases
Tumours are heterogeneous cell populations that undergo clonal evolution during tumour progression, metastasis and response to therapy. Short hairpin RNAs (shRNAs) generate stable loss-of-function phenotypes and are versatile experimental tools to explore the contribution of individual genetic alter...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4059931/ https://ncbi.nlm.nih.gov/pubmed/24889111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4981 |
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