Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

Tumours are heterogeneous cell populations that undergo clonal evolution during tumour progression, metastasis and response to therapy. Short hairpin RNAs (shRNAs) generate stable loss-of-function phenotypes and are versatile experimental tools to explore the contribution of individual genetic alter...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Charles, Joël P., Fuchs, Jeannette, Hefter, Mirjam, Vischedyk, Jonas B., Kleint, Maximilian, Vogiatzi, Fotini, Schäfer, Jonas A., Nist, Andrea, Timofeev, Oleg, Wanzel, Michael, Stiewe, Thorsten
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Pub. Group 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059931/
https://ncbi.nlm.nih.gov/pubmed/24889111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4981
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