Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

Tumours are heterogeneous cell populations that undergo clonal evolution during tumour progression, metastasis and response to therapy. Short hairpin RNAs (shRNAs) generate stable loss-of-function phenotypes and are versatile experimental tools to explore the contribution of individual genetic alter...

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Bibliografiska uppgifter
Huvudupphovsmän: Charles, Joël P., Fuchs, Jeannette, Hefter, Mirjam, Vischedyk, Jonas B., Kleint, Maximilian, Vogiatzi, Fotini, Schäfer, Jonas A., Nist, Andrea, Timofeev, Oleg, Wanzel, Michael, Stiewe, Thorsten
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Group 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059931/
https://ncbi.nlm.nih.gov/pubmed/24889111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4981
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