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Transcriptome Profiling of NIH3T3 Cell Lines Expressing Opsin and the P23H Opsin Mutant Identifies Candidate Drugs for the Treatment of Retinitis Pigmentosa

Mammalian cells are commonly employed in screening assays to identify active compounds that could potentially affect the progression of different human diseases including retinitis pigmentosa (RP), a class of inherited diseases causing retinal degeneration with compromised vision. Using transcriptom...

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Bibliographische Detailangaben
Veröffentlicht in:Pharmacol Res
Hauptverfasser: Chen, Yuanyuan, Brooks, Matthew J, Gieser, Linn, Swaroop, Anand, Palczewski, Krzysztof
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5205556/
https://ncbi.nlm.nih.gov/pubmed/27838510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.10.031
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