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Pharmacological Chaperone-mediated in Vivo Folding and Stabilization of the P23H-opsin Mutant Associated with Autosomal Dominant Retinitis Pigmentosa

Protein conformational disorders, which include certain types of retinitis pigmentosa, are a set of inherited human diseases in which mutant proteins are misfolded and often aggregated. Many opsin mutants associated with retinitis pigmentosa, the most common being P23H, are misfolded and retained wi...

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מידע ביבליוגרפי
Main Authors: Noorwez, Syed M., Kuksa, Vladimir, Imanishi, Yoshikazu, Zhu, Li, Filipek, Sławomir, Palczewski, Krzysztof, Kaushal, Shalesh
פורמט: Artigo
שפה:Inglês
יצא לאור: 2003
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361689/
https://ncbi.nlm.nih.gov/pubmed/12566452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M300087200
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