SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

PURPOSE: Mutations in RHO, the gene for a rhodopsin, are a leading cause of autosomal dominant retinitis pigmentosa. The objective of this study was to determine if a synthetic retinal analogue (SRD005825) serves as a pharmacologic chaperone to promote appropriate membrane trafficking of a mutant ve...

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Bibliografiska uppgifter
I publikationen:Transl Vis Sci Technol
Huvudupphovsmän: Ahmed, Chulbul M., Dwyer, Brian T., Romashko, All, Van Adestine, Stev, Park, Eun-He, Lou, Zhe, Welty, Devi, Josiah, Seren, Savinainen, Annel, Zhang, Bohon, Lewin, Alfred S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Association for Research in Vision and Ophthalmology 2019
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910612/
https://ncbi.nlm.nih.gov/pubmed/31857914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.8.6.30
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