Probing Mechanisms of Photoreceptor Degeneration in a New Mouse Model of the Common Form of Autosomal Dominant Retinitis Pigmentosa due to P23H Opsin Mutations

Rhodopsin, the visual pigment mediating vision under dim light, is composed of the apoprotein opsin and the chromophore ligand 11-cis-retinal. A P23H mutation in the opsin gene is one of the most prevalent causes of the human blinding disease, autosomal dominant retinitis pigmentosa. Although P23H c...

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Hlavní autoři: Sakami, Sanae, Maeda, Tadao, Bereta, Grzegorz, Okano, Kiichiro, Golczak, Marcin, Sumaroka, Alexander, Roman, Alejandro J., Cideciyan, Artur V., Jacobson, Samuel G., Palczewski, Krzysztof
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060508/
https://ncbi.nlm.nih.gov/pubmed/21224384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209759
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