Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate

Inactivating mutations in the retinoid isomerase (RPE65) or lecithin:retinol acyltransferase (LRAT) genes cause Leber congenital amaurosis (LCA), a severe visual impairment in humans. Both enzymes participate in the retinoid (visual) cycle, the enzymatic pathway that continuously generates 11-cis-re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Maeda, Tadao, Cideciyan, Artur V., Maeda, Akiko, Golczak, Marcin, Aleman, Tomas S., Jacobson, Samuel G., Palczewski, Krzysztof
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2009
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685761/
https://ncbi.nlm.nih.gov/pubmed/19339306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp163
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