Trafficking of Membrane-Associated Proteins to Cone Photoreceptor Outer Segments Requires the Chromophore 11-cis-Retinal

Lecithin retinol acyl transferase (LRAT) and retinal pigment epithelium protein 65 (RPE65) are key enzymes of the retinoid cycle. In Lrat(−/−) and Rpe65(−/−) mice, models of human Leber congenital amaurosis, the retinoid cycle is disrupted and 11-cis-retinal, the chromophore of visual pigments, is n...

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Main Authors: Zhang, Houbin, Fan, Jie, Li, Sha, Karan, Sukanya, Rohrer, Baerbel, Palczewski, Krzysztof, Frederick, Jeanne M., Crouch, Rosalie K., Baehr, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562706/
https://ncbi.nlm.nih.gov/pubmed/18400900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0317-08.2008
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