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Light Prevents Exogenous 11-cis Retinal from Maintaining Cone Photoreceptors in Chromophore-Deficient Mice

PURPOSE. To determine the effect of light/dark cycles on the cones of 11-cis retinal–treated RPE65/rhodopsin double knockout (Rpe65(−/−)Rho(−/−)) mice. Studies have shown that cones degenerate in chromophore-deficient mouse models for Leber Congenital Amaurosis (LCA), but exogenous supplementation o...

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Detalhes bibliográficos
Main Authors: Fan, Jie, Crouch, Rosalie K., Kono, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Association for Research in Vision and Ophthalmology, Inc. 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081252/
https://ncbi.nlm.nih.gov/pubmed/21228385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6437
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