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Light Prevents Exogenous 11-cis Retinal from Maintaining Cone Photoreceptors in Chromophore-Deficient Mice
PURPOSE. To determine the effect of light/dark cycles on the cones of 11-cis retinal–treated RPE65/rhodopsin double knockout (Rpe65(−/−)Rho(−/−)) mice. Studies have shown that cones degenerate in chromophore-deficient mouse models for Leber Congenital Amaurosis (LCA), but exogenous supplementation o...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Association for Research in Vision and Ophthalmology, Inc.
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081252/ https://ncbi.nlm.nih.gov/pubmed/21228385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6437 |
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