Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization

The pathophysiology of the E150K mutation in the rod opsin gene associated with autosomal recessive retinitis pigmentosa (arRP) has yet to be determined. We generated knock-in mice carrying a single nucleotide change in exon 2 of the rod opsin gene resulting in the E150K mutation. This novel mouse m...

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Bibliographic Details
Main Authors: Zhang, Ning, Kolesnikov, Alexander V., Jastrzebska, Beata, Mustafi, Debarshi, Sawada, Osamu, Maeda, Tadao, Genoud, Christel, Engel, Andreas, Kefalov, Vladimir J., Palczewski, Krzysztof
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533307/
https://ncbi.nlm.nih.gov/pubmed/23221340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66176
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