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Inherent Instability of the Retinitis Pigmentosa P23H Mutant Opsin

The P23H opsin mutation is the most common cause of autosomal dominant retinitis pigmentosa. Even though the pathobiology of the resulting retinal degeneration has been characterized in several animal models, its complex molecular mechanism is not well understood. Here, we expressed P23H bovine rod...

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Autores principales: Chen, Yuanyuan, Jastrzebska, Beata, Cao, Pengxiu, Zhang, Jianye, Wang, Benlian, Sun, Wenyu, Yuan, Yiyuan, Feng, Zhaoyang, Palczewski, Krzysztof
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979360/
https://ncbi.nlm.nih.gov/pubmed/24515108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551713
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