Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

BACKGROUND: Human embryonic stem cells (hESCs) partially recapitulate early embryonic three germ layer development, allowing testing of potential teratogenic hazards. Because use of hESCs is ethically debated, we investigated the potential for human induced pluripotent stem cells (hiPSCs) to replace...

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Bibliografski detalji
Izdano u:Stem Cell Res Ther
Glavni autori: Shinde, Vaibhav, Perumal Srinivasan, Sureshkumar, Henry, Margit, Rotshteyn, Tamara, Hescheler, Jürgen, Rahnenführer, Jörg, Grinberg, Marianna, Meisig, Johannes, Blüthgen, Nils, Waldmann, Tanja, Leist, Marcel, Hengstler, Jan Georg, Sachinidis, Agapios
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203708/
https://ncbi.nlm.nih.gov/pubmed/28038682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0449-2
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