Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

BACKGROUND: Human embryonic stem cells (hESCs) partially recapitulate early embryonic three germ layer development, allowing testing of potential teratogenic hazards. Because use of hESCs is ethically debated, we investigated the potential for human induced pluripotent stem cells (hiPSCs) to replace...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Shinde, Vaibhav, Perumal Srinivasan, Sureshkumar, Henry, Margit, Rotshteyn, Tamara, Hescheler, Jürgen, Rahnenführer, Jörg, Grinberg, Marianna, Meisig, Johannes, Blüthgen, Nils, Waldmann, Tanja, Leist, Marcel, Hengstler, Jan Georg, Sachinidis, Agapios
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203708/
https://ncbi.nlm.nih.gov/pubmed/28038682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0449-2
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