Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests

Stem cell-based in vitro test systems can recapitulate specific phases of human development. In the UKK test system, human pluripotent stem cells (hPSCs) randomly differentiate into cells of the three germ layers and their derivatives. In the UKN1 test system, hPSCs differentiate into early neural p...

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Опубликовано в: :Arch Toxicol
Главные авторы: Shinde, Vaibhav, Hoelting, Lisa, Srinivasan, Sureshkumar Perumal, Meisig, Johannes, Meganathan, Kesavan, Jagtap, Smita, Grinberg, Marianna, Liebing, Julia, Bluethgen, Nils, Rahnenführer, Jörg, Rempel, Eugen, Stoeber, Regina, Schildknecht, Stefan, Förster, Sunniva, Godoy, Patricio, van Thriel, Christoph, Gaspar, John Antonydas, Hescheler, Jürgen, Waldmann, Tanja, Hengstler, Jan G., Leist, Marcel, Sachinidis, Agapios
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2016
Предметы:
In vitro Systems
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5306084/
https://ncbi.nlm.nih.gov/pubmed/27188386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1741-8
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