A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a related mode of action can be identified and grouped for read-across. We chose a test system of develop...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Rempel, Eugen, Hoelting, Lisa, Waldmann, Tanja, Balmer, Nina V., Schildknecht, Stefan, Grinberg, Marianna, Das Gaspar, John Antony, Shinde, Vaibhav, Stöber, Regina, Marchan, Rosemarie, van Thriel, Christoph, Liebing, Julia, Meisig, Johannes, Blüthgen, Nils, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., Leist, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
In Vitro Systems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551554/
https://ncbi.nlm.nih.gov/pubmed/26272509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1573-y
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