A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a related mode of action can be identified and grouped for read-across. We chose a test system of develop...

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Dettagli Bibliografici
Pubblicato in:Arch Toxicol
Autori principali: Rempel, Eugen, Hoelting, Lisa, Waldmann, Tanja, Balmer, Nina V., Schildknecht, Stefan, Grinberg, Marianna, Das Gaspar, John Antony, Shinde, Vaibhav, Stöber, Regina, Marchan, Rosemarie, van Thriel, Christoph, Liebing, Julia, Meisig, Johannes, Blüthgen, Nils, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., Leist, Marcel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2015
Soggetti:
In Vitro Systems
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551554/
https://ncbi.nlm.nih.gov/pubmed/26272509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1573-y
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