A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a related mode of action can be identified and grouped for read-across. We chose a test system of develop...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Arch Toxicol
Egile Nagusiak: Rempel, Eugen, Hoelting, Lisa, Waldmann, Tanja, Balmer, Nina V., Schildknecht, Stefan, Grinberg, Marianna, Das Gaspar, John Antony, Shinde, Vaibhav, Stöber, Regina, Marchan, Rosemarie, van Thriel, Christoph, Liebing, Julia, Meisig, Johannes, Blüthgen, Nils, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., Leist, Marcel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Berlin Heidelberg 2015
Gaiak:
In Vitro Systems
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551554/
https://ncbi.nlm.nih.gov/pubmed/26272509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1573-y
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak