Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes

Studies of Leishmania donovani have shown that both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for promastigote proliferation and required for maximum infection in mice. However, the importance of arginase (ARG), the first enzyme...

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Détails bibliographiques
Publié dans:Infect Immun
Auteurs principaux: Boitz, Jan M., Gilroy, Caslin A., Olenyik, Tamara D., Paradis, Dustin, Perdeh, Jasmine, Dearman, Kristie, Davis, Madison J., Yates, Phillip A., Li, Yuexin, Riscoe, Michael K., Ullman, Buddy, Roberts, Sigrid C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203656/
https://ncbi.nlm.nih.gov/pubmed/27795357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00554-16
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