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IMP Dehydrogenase Deficiency in Leishmania donovani Causes a Restrictive Growth Phenotype in Promastigotes but is not Essential for Infection in Mice
Leishmania cannot synthesize purines de novo and therefore must scavenge purines from its host for survival and growth. Biochemical and genomic analyses have indicated that Leishmania species express three potential routes for the synthesis of guanylate nucleotides: 1) a two-step pathway that conver...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3202435/ https://ncbi.nlm.nih.gov/pubmed/21907738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2011.08.006 |
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