The Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled Oligomerization

The final two steps of de novo uridine 5′-monophosphate (UMP) biosynthesis are catalyzed by orotate phosphoribosyltransferase (OPRT) and orotidine 5′-monophosphate decarboxylase (OMPDC). In most prokaryotes and simple eukaryotes these two enzymes are encoded by separate genes, whereas in mammals the...

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Bibliographic Details
Main Authors: French, Jarrod B., Yates, Phillip A., Soysa, D. Radika, Boitz, Jan M., Carter, Nicola S., Chang, Bailey, Ullman, Buddy, Ealick, Steven E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121495/
https://ncbi.nlm.nih.gov/pubmed/21507942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228213
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