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Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes

Studies of Leishmania donovani have shown that both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for promastigote proliferation and required for maximum infection in mice. However, the importance of arginase (ARG), the first enzyme...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Boitz, Jan M., Gilroy, Caslin A., Olenyik, Tamara D., Paradis, Dustin, Perdeh, Jasmine, Dearman, Kristie, Davis, Madison J., Yates, Phillip A., Li, Yuexin, Riscoe, Michael K., Ullman, Buddy, Roberts, Sigrid C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203656/
https://ncbi.nlm.nih.gov/pubmed/27795357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00554-16
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