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Adenylosuccinate Synthetase and Adenylosuccinate Lyase Deficiencies Trigger Growth and Infectivity Deficits in Leishmania donovani

Leishmania are auxotrophic for purines, and consequently purine acquisition from the host is a requisite nutritional function for the parasite. Both adenylosuccinate synthetase (ADSS) and adenylosuccinate lyase (ASL) have been identified as vital components of purine salvage in Leishmania donovani,...

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Detalhes bibliográficos
Main Authors: Boitz, Jan M., Strasser, Rona, Yates, Phillip A., Jardim, Armando, Ullman, Buddy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610970/
https://ncbi.nlm.nih.gov/pubmed/23404497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431486
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